Use of enamel matrix- derived proteins combined with bone graft for the treatment of intrabony defects: Overview of reviews (FRISBEE review)
Abstract
Introduction: The use of enamel matrix-derived proteins (EMD) has increased in recent years due to their tissue-inducing properties that support periodontal regeneration. This study is an overview of systematic reviews with FRISBEE methodology on the use of EMD alone or combined with autologous bone graft materials (BGM) in the treatment of intrabony defects.
Materials and Methods: A systematic search in the Epistemonikos database was performed. RevMan 5.3 and GRADEpro were used for data analysis and presentation
Results: Four systematic reviews and two clinical trials were identified. All studies analysed change in probing depth, clinical attachment level, gingival margin level and bone defect depth (all changes in favour of EMD+BGM groups: mean difference (MD): 0.37 mm more, MD: 0.7 mm more, MD: 0.3 mm less, MD: 0.75 more, respectively).
Conclusions: Adding autologous bone graft to EMD to treat intrabony defects showed better results, but not a relevant clinical difference compared to the use of EMD alone.
Keywords: Dental enamel proteins; Bone transplantation; Autologous transplantation; Alveolar bone loss; Periodontal diseases; Bone regeneration.
References
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17. Guida L, Annunziata M, Belardo S, Farina R, Scabbia A, Trombelli L. Effect of autogenous cortical bone particulate in conjunction with enamel matrix derivative in the treatment of periodontal intrabony defects. J Periodontol. 2007;78(2):231-238. doi:10.1 902/JOP.2007.060142
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20. Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Glasziou P, Jaeschke R, Akl EA, Norris S, Vist G, Dahm P, Shukla VK, Higgins J, Falck-Ytter Y, Schünemann HJ; GRADE Working Group. GRADE guidelines: 7. Rating the quality of evidence--inconsistency. J Clin Epidemiol. 2011;64(12):1294-302. doi: 10.1016/j.jclinepi.2011.03.017. Epub 2011 Jul 31. PMID: 21803546.
21. Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Falck-Ytter Y, Jaeschke R, Vist G, Akl EA, Post PN, Norris S, Meerpohl J, Shukla VK, Nasser M, Schünemann HJ; GRADE Working Group. GRADE guidelines: 8. Rating the quality of evidence--indirectness. J Clin Epidemiol. 2011;64(12):1303-10. doi: 10.1016/j.jclinepi.2011.04.014. Epub 2011 Jul 30. PMID: 21802903.
22. Girón J, Kerstner E, Medeiros T, Oliveira L, Machado GM, Malfatti CF, Pranke P. Biomaterials for bone regeneration: an orthopedic and dentistry overview. Braz J Med Biol Res. 2021;54(9):e11055. doi: 10.1590/1414-431X2021e11055. PMID: 34133539; PMCID: PMC8208772.
23. Imamura K, saito A, Aoki H, Ishizuka Y. Clinical Outcomes of Periodontal Regeneration for intrabony defects using Recombinant Human FGF-2 or Enamel Matrix Derivative: A Systematic Review and Meta-Analysis. PROSPERO. Published 2021. Accessed February 27, 2022. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=247113
24. Regidor E, Morante S, Lorenzo R, Gross E, Ortiz-Vigón A. Eficacia clínica en el tratamiento de defectos críticos del proceso alveolar mediante aloinjertos óseos corticales. Rev científica la Soc Española Periodoncia. 2021;19(2):37-50.
2. Kassebaum NJ, Bernabe E, Dahiya M, Bhandari B, Murray CJL, Marcenes W. Global Burden of Severe Periodontitis in 1990-2010: A Systematic Review and Meta-regression. J Dent Res. 2014;93(11):1053. doi:10.1177/0022034514552491
3. Melo JGA, Sousa JP, Firmino RT, Matins CC, Granville-Garcia AF, Nonaka CFW, Costa EMMB. Different applications forms of green tea (Camellia sinensis (L.) Kuntze) for the treatment of periodontitis: a systematic review and meta-analysis. J Periodontal Res. 2021;56(3):443-453. doi: 10.1111/jre.12871. Epub 2021 Mar 17. PMID: 33729563.
4. Shukla S, Chug A, Mahesh L, Singh S, Singh K. Optimal management of intrabony defects: current insights. Clin Cosmet Investig Dent. Published online 2019:25. doi:10.2147/CCIDE.S166164
5. Nibali L, Koidou V, Salomone S, Hamborg T, Allaker R, Ezra R, Zou L, Tsakos G, Gkranias N, Donos N. Minimally invasive non-surgical vs. surgical approach for periodontal intrabony defects: a randomised controlled trial. Trials. 2019;20(1):461. doi: 10.1186/s13063-019-3544-8. PMID: 31351492; PMCID: PMC6660941.
6. Majzoub J, Salami A, Barootchi S, Tavelli L, Chan HL, Wang HL. The effect of non-surgical and surgical mechanical root debridement on infrabony defects: a retrospective study. Sci Rep. 2021;11(1):19856. doi:10.1038/S41598-021-99205-Z
7. Miron RJ, Sculean A, Cochran DL, Froum S, Zucchelli G, Nemcovsky C, Donos N, Lyngstadaas SP, Deschner J, Dard M, Stavropoulos A, Zhang Y, Trombelli L, Kasaj A, Shirakata Y, Cortellini P, Tonetti M, Rasperini G, Jepsen S, Bosshardt DD. Twenty years of enamel matrix derivative: the past, the present and the future. J Clin Periodontol. 2016;43(8):668-83. doi: 10.1111/jcpe.12546. Epub 2016 May 28. PMID: 26987551.
8. Esposito M, Grusovin MG, Papanikolaou N, Coulthard P, Worthington HV. Enamel matrix derivative (Emdogain(R)) for periodontal tissue regeneration in intrabony defects. Cochrane Database Syst Rev. 2009;2009(4):CD003875. doi: 10.1002/14651858.CD003875.pub3. PMID: 19821315; PMCID: PMC6786880.
9. Annunziata M, Piccirillo A, Perillo F, Cecoro G, Nastri L, Guida L. Enamel Matrix Derivative and Autogenous Bone Graft for Periodontal Regeneration of Intrabony Defects in Humans: A Systematic Review and Meta-Analysis. Materials (Basel). 2019;12(16):2634. doi: 10.3390/ma12162634. PMID: 31430899; PMCID: PMC6719005.
10. Troiano G, Laino L, Zhurakivska K, Cicciù M, Lo Muzio L, Lo Russo L. Addition of enamel matrix derivatives to bone substitutes for the treatment of intrabony defects: A systematic review, meta-analysis and trial sequential analysis. J Clin Periodontol. 2017;44(7):729-738. doi: 10.1111/jcpe. 12742. Epub 2017 Jun 23. PMID: 28477366.
11. Dallaserra M, Moreno B, Muñoz M, et al. Resumen estructurado de Revisiones Sistemáticas (FRISBEE). Rev clínica periodoncia, Implantol y Rehabil oral. 2019;12(2):113-115. doi:10.4067/S0719-01072019000 200113
12. Verdugo-Paiva F, Zambrano-Achig P, Simancas-Racines D, Viteri-García A. Remoción selectiva comparado con remoción total para caries dentinarias profundas. Medwave. 2020;20(01):e7758. doi:10.58 67/MEDWAVE.2020.01.7758
13. Matarasso M, Iorio-Siciliano V, Blasi A, Ramaglia L, Salvi GE, Sculean A. Enamel matrix derivative and bone grafts for periodontal regeneration of intrabony defects. A systematic review and meta-analysis. Clin Oral Investig. 2015;19(7):1581-1593. doi:10.1007/S00784-015-1491-7
14. Li W, Xiao L, Hu J. The use of enamel matrix derivative alone versus in combination with bone grafts to treat patients with periodontal intrabony defects: a meta-analysis. J Am Dent Assoc. 2012;143(9):e46-e56. doi:10.14219/JADA.ARCHIVE.2012.0327
15. Kao RT, Nares S, Reynolds MA. Periodontal Regeneration – Intrabony Defects: A Systematic Review From the AAP Regeneration Workshop. J Periodontol. 2015;86(2-s):S77-S104. doi:10.1902/JOP.2015.130685
16. Yilmaz S, Cakar G, Yildirim B, Sculean A. Healing of two and three wall intrabony periodontal defects following treatment with an enamel matrix derivative combined with autogenous bone. J Clin Periodontol. 2010;37(6):544-550. doi:10.1111/J.16 00-051X.2010.01567.X
17. Guida L, Annunziata M, Belardo S, Farina R, Scabbia A, Trombelli L. Effect of autogenous cortical bone particulate in conjunction with enamel matrix derivative in the treatment of periodontal intrabony defects. J Periodontol. 2007;78(2):231-238. doi:10.1 902/JOP.2007.060142
18. Guyatt GH, Oxman AD, Vist G, Kunz R, Brozek J, Alonso-Coello P, Montori V, Akl EA, Djulbegovic B, Falck-Ytter Y, Norris SL, Williams JW Jr, Atkins D, Meerpohl J, Schünemann HJ. GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias). J Clin Epidemiol. 201164(4):407-15. doi: 10.1016/j.jclinepi.2010.07.017. Epub 2011 Jan 19. PMID: 21247734.
19. Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines 6. Rating the quality of evidence—imprecision. J Clin Epidemiol. 2011;64(12):1283-1293. doi:10.1016/J.JCLINEPI.2011.01.012
20. Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Glasziou P, Jaeschke R, Akl EA, Norris S, Vist G, Dahm P, Shukla VK, Higgins J, Falck-Ytter Y, Schünemann HJ; GRADE Working Group. GRADE guidelines: 7. Rating the quality of evidence--inconsistency. J Clin Epidemiol. 2011;64(12):1294-302. doi: 10.1016/j.jclinepi.2011.03.017. Epub 2011 Jul 31. PMID: 21803546.
21. Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Falck-Ytter Y, Jaeschke R, Vist G, Akl EA, Post PN, Norris S, Meerpohl J, Shukla VK, Nasser M, Schünemann HJ; GRADE Working Group. GRADE guidelines: 8. Rating the quality of evidence--indirectness. J Clin Epidemiol. 2011;64(12):1303-10. doi: 10.1016/j.jclinepi.2011.04.014. Epub 2011 Jul 30. PMID: 21802903.
22. Girón J, Kerstner E, Medeiros T, Oliveira L, Machado GM, Malfatti CF, Pranke P. Biomaterials for bone regeneration: an orthopedic and dentistry overview. Braz J Med Biol Res. 2021;54(9):e11055. doi: 10.1590/1414-431X2021e11055. PMID: 34133539; PMCID: PMC8208772.
23. Imamura K, saito A, Aoki H, Ishizuka Y. Clinical Outcomes of Periodontal Regeneration for intrabony defects using Recombinant Human FGF-2 or Enamel Matrix Derivative: A Systematic Review and Meta-Analysis. PROSPERO. Published 2021. Accessed February 27, 2022. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=247113
24. Regidor E, Morante S, Lorenzo R, Gross E, Ortiz-Vigón A. Eficacia clínica en el tratamiento de defectos críticos del proceso alveolar mediante aloinjertos óseos corticales. Rev científica la Soc Española Periodoncia. 2021;19(2):37-50.
Published
2023-09-30
How to Cite
PARISE-VASCO, Juan Marcos; GAVILÁNEZ-SÁNCHEZ, Andrea; MONTESINOS-GUEVARA, Camila.
Use of enamel matrix- derived proteins combined with bone graft for the treatment of intrabony defects: Overview of reviews (FRISBEE review).
Journal of Oral Research, [S.l.], v. 12, n. 1, p. 127-138, sep. 2023.
ISSN 0719-2479.
Available at: <https://joralres.com/index.php/JOralRes/article/view/joralres.2023.012>. Date accessed: 02 may 2024.
doi: https://doi.org/10.17126/joralres.2023.012.
Issue
Section
Reviews
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