Association of serum level of 25-hydroxy vitamin D with Oral Lichen Planus. A case-control study.

  • Mostafa Sadeghi Qazvin University of Medical Sciences, Qazvin, Iran.
  • Mahdieh Zarabadipour Dental Caries Prevention Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
  • Faezeh Azmodeh Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran.
  • Monirsadat Mirzadeh Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
  • Ali Sarbazi Golezari Qazvin University of Medical Sciences, Qazvin, Iran.


Introduction: Vitamin D deficiency is a global health problem that can be a risk factor for a broad range of diseases such as some autoimmune diseases. Due to the autoimmune base of lichen planus, it seems that a reduction of the serum level of vitamin D is related to lichen planus. In this study, we investigate the relation between serum level of vitamin D and oral lichen planus patients (OLP). Material and Methods: In this case-control study, 35 patients with OLP (including 15 men and 20 women) and 70 healthy volunteers (including 35 men and 35 women), aged between 30-60 years old, referred to Qazvin University of Medical Sciences were investigated. None of these volunteers had systemic diseases. Vitamin D levels were measured with ELFA (Enzyme Linked Fluorescent Assay) and the data was analyzed using the chi-squared test and t-test. Results: The mean serum level of vitamin D in the control group was 23.7±9ng/ml and in the case group was 18.12±8/7ng/ml. The results show that the serum level of vitamin D in patients with OLP is significantly less than in the control group (p<0.05). Conclusion: According to the results, the serum level of vitamin D in patients with OLP was significantly lower than that of healthy people.


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How to Cite
SADEGHI, Mostafa et al. Association of serum level of 25-hydroxy vitamin D with Oral Lichen Planus. A case-control study.. Journal of Oral Research, [S.l.], v. 9, n. 5, p. 400-404, oct. 2020. ISSN 0719-2479. Available at: <>. Date accessed: 08 feb. 2023. doi: