The effects of luteolin nanoparticles on the healing of extracted tooth socket in rabbits.
Abstract
Objective: To evaluate the effects of luteolin nanoparticles on the process tooth socket healing in rabbits. Design: This study comprised five rabbits randomly assigned to control animal and experimental animals. Immediately after the extraction of an upper maxillary incisor, the alveolar sockets of experimental animals were treated with topical luteolin while alveolar sockets of the control group remained without treatment. The animals were sacrificed by decapitation with deep anesthesia seven days post tooth extraction. The tooth sockets were sectioned and stained with hematoxylin and eosin stains. Results: Histological evaluation revealed that luteolin treatment induced earlier healing of extracted tooth sockets. Conclusion: These findings suggest that luteolin accelerates the healing process in tooth sockets of rabbits.
References
2. Farina R, Trombelli L. Wound healing of extraction sockets. Endodontic Topics .2012;25:16-43.
3. Amler MH. Disturbed healing of extracted wounds. J Oral Implantol. 1999; 25(3): 179-84.
4. Bayrami Z, Khalighi-Sigaroodi F, Rahimi R. In vitro wound healing activity of luteolin. Res J Pharmacognosy. 2017;4(Supplement):7
5. Ilyas MH, Fahim A, Awan U. Effect of Honey on Healing of Extracted Tooth Socket of Albino Wista Rats. Int Med J. 2015;22(5): 422-5.
6. Ayoub AH, Agbor AM. Comparative Study of Extraction Socket Preservation Using Autogenous PRF and TCP. EC Dent Scie. 2017;8(1) : 26-37.
7. Prasad SD, Rajesh JM, Ashish S, Prasad RG. Effect of honey on rate of healing of socket after tooth extraction in rabbits. Pharmacology. 2017:4-6.
8. Palombo R, Savini I, Avigliano L, Madonna S, Cavani A, Albanesi C, Mauriello A, Melino G, Terrinoni A. Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model. Cell Death Dis. 2016;7(8):e2344.
9. Sochen JE. Orthopedic wounds. Amer J Surg 1994; 167: 52S-4S.
10. Odontuya G, Hoult JR, Houghton PJ. Structure-activity relationship for antiinflammatory effect of luteolin and its derived glycosides. Phytother Res. 2005;19(9):782-6.
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