Evaluation of direct pulp capping with a synthetic chalcone: a preliminary histological study.

  • David Rivero Tames Department of Cell and Tissue Biology, Laboratory of Histology, University of Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina.
  • Bruna Laís Tanello Department of Cell and Tissue Biology, Laboratory of Histology, University of Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina.
  • María Helena Carpeggiani Department of Cell and Tissue Biology, Laboratory of Histology, University of Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina.
  • Xana Raquel Ortolan Department of Cell and Tissue Biology, Laboratory of Histology, University of Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina.
  • Fatima de Campos-Buzzi Department of Chemistry, Chemical-Pharmaceutical Investigations Center (NIQFAR)/CCS, University of Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina.
  • Rogério Corrêa Department of Chemistry, Chemical-Pharmaceutical Investigations Center (NIQFAR)/CCS, University of Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina.
  • Telmo José Mezadri Department of Sciences/Histology, Laboratory of Histology, University of Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina.
DOI: https://doi.org/10.17126/joralres.2015.040

Abstract

Objective: The aim of this study is to evaluate the action of the synthetic chalcone 1-phenyl-3-(4-chlorophenyl)-2-propen-1-one to induce pulp healing in rats. Material and Methods: Sixty lower first molars of male Wistar rats were divided into 3 groups (n= 20): control (no treatment); calcium hydroxide and chalcone. After relative isolation, the cavities were prepared using a sterile low-speed ¼ round dental bur. After controlling the hemorrhaging, all the pulp exposures were capped with the capping material, by groups. The cavities were sealed with glass ionomer cement and the repair process was assessed at 21 days of procedure. The data were statistically analyzed using the Fisher exact test (p<0.05). Results: Moderate inflammation was observed in all the experimental groups and significant (p<0.05) reparative dentin (tertiary) formation in the calcium hydroxide and chalcone groups. The chalcone group showed dentinal tubules and a low number of cellular inclusions (p<0.05). Conclusion: The chalcone used in this study indicates potential as an inducer of reparative dentine (tertiary) in a rat model.

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Published
2015-06-21
How to Cite
TAMES, David Rivero et al. Evaluation of direct pulp capping with a synthetic chalcone: a preliminary histological study.. Journal of Oral Research, [S.l.], v. 4, n. 3, p. 205-210, june 2015. ISSN 0719-2479. Available at: <https://joralres.com/index.php/JOralRes/article/view/joralres.2015.040>. Date accessed: 28 apr. 2024. doi: https://doi.org/10.17126/joralres.2015.040.
Citation Formats
Issue
Vol 4 No 3
Section
Articles

Keywords

Chalcone; Dental pulp capping; Wistar rats.

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