Immune system and zinc are associated with recurrent aphthous stomatitis. An assessment using a network-based approach.

  • Cesar Rivera Department of Biomedical Sciences, Faculty of Health Sciences, University of Talca, Talca. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba. Brazilian Biosciences National Laboratory (LNBio), National Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo.

Abstract

Objective: The aim of this research was to identify genes, proteins and processes from the biomedical information published on recurrent aphthous stomatitis (RAS) using network-based foci. Methods: The clinical context was defined using MeSH terms for RAS and biomarkers, combined with words associated with risk. A set of protein coding genes was prioritized using the Génie web server and classified with PANTHER. For defining biologically relevant proteins, protein-protein interaction networks were constructed using Reactome database and Cytoscape. Top 20 proteins were then subjected to functional enrichment using STRING. Results: From 1,075,576 gene-abstract links, 1,491 genes were prioritized. Proteins were related to signaling molecule proteins (n=221), receptor proteins (n=221) and nucleic acid binding proteins (n=169). The network constructed with these proteins included 3,963 nodes and functional analysis showed that main processes involved immune system and zinc ion binding function. Conclusions: For the first time, bioinformatics tools were used for integrating pathways and networks associated with RAS. Molecules and processes associated with immune system recur robustly in all analyzed information. The molecular zinc ion binding function could be an area for exploring more specific and effective therapeutic interventions.

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Published
2017-09-28
How to Cite
RIVERA, Cesar. Immune system and zinc are associated with recurrent aphthous stomatitis. An assessment using a network-based approach.. Journal of Oral Research, [S.l.], v. 6, n. 9, p. 245-251, sep. 2017. ISSN 0719-2479. Available at: <https://joralres.com/index.php/JOralRes/article/view/joralres.2017.069>. Date accessed: 28 mar. 2024. doi: https://doi.org/10.17126/joralres.2017.069.
Section
Articles

Keywords

recurrent aphthous stomatitis; pathogenesis; protein interaction maps; immune system; zinc.