Traumatic ulcerative granuloma with stromal eosinophilia, an unusual clinical manifestation in the oral mucosa. Case report.

  • Camila Muñoz-Grez Facultad de Odontología, Universidad de Concepción, Concepción, Chile.
  • Constanza Ulloa-Bequer Departamento de Patología y Diagnóstico. Facultad de Odontología,Universidad de Concepción, Concepción. Chile.

Abstract

Introduction: Traumatic ulcerative granuloma with stromal eosinophilia is an uncommon condition of the oral mucosa with a chronic course, usually affecting the tongue. Case Report: Clinically it presents as a chronic ulcer, with raised and indurated borders, rarely presented as a tumor. Histologically it shows a diffuse mixed inflammatory infiltrate, rich in eosinophils. The etiology of this lesion is still unclear; however, chronic irritation from traumatic agents is considered a major initiating factor. In some cases, the presence of CD30+ mononuclear cells within the lesions suggest the possibility of a CD30+ lymphoproliferative disorder. This article presents a case of a traumatic ulcerative granuloma with stromal eosinophilia manifested in a 56-year-old female with a solitary ulcerated tumor inside the right cheek. Conclusion: It was diagnosed based on clinical data and histopathological features. In a brief literature review, the entity has been characterized, analyzing its etiology and nature.

References

1. Shen WR, Chang JY, Wu YC, Cheng SJ, Chen HM, Wang YP. Oral traumatic ulcerative granuloma with stromal eosinophilia: A clinicopathological study of 34 cases. J Formos Med Assoc. 2015;114(9):881-5.
2. Sharma B, Koshy G, Kapoor S. Traumatic Ulcerative Granuloma with Stromal Eosinophila: A Case Report and Review of Pathogenesis. J Clin Diagn Res. 2016;10(10):ZD07-ZD09.
3. Elzay RP, Richmond V. Traumatic ulcerative granuloma with stromal eosinophilia (Riga-Fede’s disease and traumatic eosinophilic granuloma). Oral Surg Oral Med Oral Pathol. 1983;55: 497–506.
4. Marszalek A, Neska-Dlugosz I. Traumatic ulcerative granuloma with stromal eosinophilia. A case report and short literature review. Pol J Pathol. 2011;62:172-5.
5. Salisbury CL,Budnick SD, Li S. T-cell receptor gene rearrangement and CD30 immunoreactivity in traumatic ulcerative granuloma with stromal eosinophilia of the oral cavity. Am J Clin Pathol. 2009; 132(5):722–7.
6. El-Mofty SK, Swanson PE, Wick MR. Miller AS. Eosinophilic ulcer of the oral mucosa: report of 38 new cases with immunohistochemical observations. Oral Surg Oral Med Oral Pathol. 1993.;75:716–22.
7. Hirshberg A, Amariglio N, Akrish S, Yahalom R, Rosenbaum H, Okon E, et al. Traumatic ulcerative granuloma with stromal eosinophilia: a reactive lesion of the oral mucosa. Am J Clin Pathol. 2006;126(4):522-9.
8. Soyele O, Adesina O, Ladeji A, Kuye K, Owotade F. Traumatic ulcerative granuloma with stromal eosinophilia: Review of the literature and case report. Afr J Med Health Sci. 2017;16 (2):115-9.
9. Bhaskar, SN, Lilly GE. Traumatic granuloma of the tongue (human and experimental). Oral Surg Oral Med Oral Pathol. 1964; 18(2): 206–18.
10. Elovic AE, Gallagher GT, Kabani S, Galli SJ, Weller PF, Wong DT. Lack of TGF-alpha and TGF-beta 1 synthesis by human eosinophils in chronic oral ulcers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;81(6):672‐81.
11. Kuriyama Y, Shimizu A, Toki S, Endo Y, Yasuda M, Motegi SI, Ishikawa O. Two cases of chronic oral ulcers effectively treated with systemic corticosteroid therapy: Circumorificial plasmacytosis and traumatic ulcerative granuloma with stromal eosinophilia. J Dermatol. 2019;46(1):48-51.
12. Ficarra G, Prignano F, Romagnoli P. Traumatic eosinophilic granuloma of the oral mucosa: a CD30+(Ki-1) lymphoproliferative disorder? Oral Oncol. 1997;33(5), 375–9.
13. Cepeda LT, Pieretti M, Chapman SF, Horenstein MG. CD30-positive atypical cells in common non-neoplastic cutaneous infiltrates rich in neutrophils and eosinophils. Am J Surg Pathol. 2003; 27(7): 912-918.
14. Alobeid B, Pan LX, Milligan L, Budel L, Frizzera G. Eosinophil-rich CD30+ lymphoproliferative disorder of the oral mucosa. Am J Clin Pathol. 2004;121:43-50
15. Chandra S, Raju S, Sah K, Anand P. Traumatic ulcerative granuloma with stromal eosinophilia. Arch Iran Med. 2014;17(1):91-94.
Published
2021-04-30
How to Cite
MUÑOZ-GREZ, Camila; ULLOA-BEQUER, Constanza. Traumatic ulcerative granuloma with stromal eosinophilia, an unusual clinical manifestation in the oral mucosa. Case report.. Journal of Oral Research, [S.l.], v. 10, n. 2, p. 1-5, apr. 2021. ISSN 0719-2479. Available at: <https://joralres.com/index.php/JOR/article/view/joralres.2021.017>. Date accessed: 21 sep. 2021. doi: https://doi.org/10.17126/joralres.2021.017.
Section
Cases