Saliva Electro-stimulation Devices (SEDs) for the Management of Xerostomia: An update.

  • Zohaib Khurshid Dept of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al-Ahsa, Saudi Arabia.
  • Sana Zohaib Dept of Biomedical Engineering, College of Engineering, King Faisal University, Al-Ahsa, Saudi Arabia.
  • Muhammad Adeel Mudasser Dr. Ishrat-ul-Ebad Khan Institute of Oral Health Sciences, Dow University of Health Sciences (DUHS), Karachi, Pakistan.
  • Eisha Imran Dept of Dental Materials, Islamic International Dental College, Riphah University, Islamabad, Pakistan.
  • Ahmed Adel Alqurani Dept of Dental Hospital, College of Dentistry, King Faisal University, Al Ahsa, Saudi Arabia.


The aim of this manuscript is to provide an overview of the past and current approaches for saliva stimulation with electro-stimulation devices (EDs) for the management of xerostomia. There are many causes and factors affecting the performance of salivary gland secretion, systematic or pathological, which compromise the lifestyle of the patient with long-term consequences that will impair health. Saliva contains a combination of many proteins, enzymes and peptides which helps in digestion, defense, and lubrication of the oral cavity. There are exceptionally good outcomes reported in the last few years from devices used to stimulate saliva via electronic impulses.


1. Khurshid Z, Zohaib S, Najeeb S, Zafar MS, Slowey PD, Almas K. Human Saliva Collection Devices for Proteomics: An Update. Int J Mol Sci. 2016;17(6):846.
2. Khurshid Z, Moin SF, Khan RS, Agwan MAS, Alwadaani AH, Zafar MS. Human salivary protein extraction from RNAPro•SAL™, Pure•SAL™, and passive drooling method. Eur J Dent. 2017;11(3):385-389.
3. Khurshid Z, Zafar M, Khan E, Mali M, Latif M. Human saliva can be a diagnostic tool for Zika virus detection. J Infect Public Health. 2019;12(5):601-604.
4. Hamid H, Khurshid Z, Adanir N, Zafar MS, Zohaib S. COVID-19 Pandemic and Role of Human Saliva as a Testing Biofluid in Point-of-Care Technology. Euro J Dent. 2020.
5. Khurshid Z, Asiri FYI, Al Wadaani H. Human Saliva: Non-Invasive Fluid for Detecting Novel Coronavirus (2019-nCoV). Int J Environ Res Public Health. 2020;17(7):2225.
6. Khurshid Z, Zafar MS, Naseem M, Khan RS, Najeeb S. Human Oral Defensins Antimicrobial Peptides: A Future Promising Antimicrobial Drug. Curr Pharm Des. 2018;24(10):1130-1137.
7. Khurshid Z, Naseem M, Yahya I Asiri F, Mali M, Sannam Khan R, Sahibzada HA, Zafar MS, Faraz Moin S, Khan E. Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health. Biomolecules. 2017;7(4):80.
8. Khurshid Z, Najeeb S, Mali M, Moin SF, Raza SQ, Zohaib S, Sefat F, Zafar MS. Histatin peptides: Pharmacological functions and their applications in dentistry. Saudi Pharm J. 2017;25(1):25-31.
9. Khurshid Z, Naseem M, Sheikh Z, Najeeb S, Shahab S, Zafar MS. Oral antimicrobial peptides: Types and role in the oral cavity. Saudi Pharm J. 2016;24(5):515-524.
10. Tanasiewicz M, Hildebrandt T, Obersztyn I. Xerostomia of Various Etiologies: A Review of the Literature. Adv Clin Exp Med. 2016;25(1):199-206.
11. Weiss WW Jr, Brenman HS, Katz P, Bennett JA. Use of an electronic stimulator for the treatment of dry mouth. J Oral Maxillofac Surg. 1986;44(11):845-50.
12. Steller M, Chou L, Daniels TE. Electrical stimulation of salivary flow in patients with Sjögren's syndrome. J Dent Res. 1988;67(10):1334-7.
13. Talal N, Quinn JH, Daniels TE. The clinical effects of electrostimulation on salivary function of Sjögren's syndrome patients. A placebo controlled study. Rheumatol Int. 1992;12(2):43-5.
14. Dawidson I, Angmar-Månsson B, Blom M, Theodorsson E, Lundeberg T. The influence of sensory stimulation (acupuncture) on the release of neuropeptides in the saliva of healthy subjects. Life Sci. 1998;63(8):659-74.
15. Koch KP, Steinmetz O, Velten T, Beiski BZ, Wolff A, Hoffmann, KP, and the Saliwell Study Group: “Stimulation device for Saliva stimulation."11th Annual Conference of the International Functional Electrical Stimulation Society in Miyagi-Zao (Japan), 280-282 (2006).
16. LeVeque FG, Montgomery M, Potter D, Zimmer MB, Rieke JW, Steiger BW, Gallagher SC, Muscoplat CC. A multicenter, randomized, double-blind, placebo-controlled, dose-titration study of oral pilocarpine for treatment of radiation-induced xerostomia in head and neck cancer patients. J Clin Oncol. 1993;11(6):1124-31.
17. Witsell DL, Stinnett S, Chambers MS. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia. Head Neck. 2012;34(8):1136-42.
18. Strietzel FP, Martín-Granizo R, Fedele S, Lo Russo L, Mignogna M, Reichart PA, Wolff A. Electrostimulating device in the management of xerostomia. Oral Dis. 2007;13(2):206-13.
19. Lee SJ, Vogelsang G, Flowers ME. Chronic graft-versushost disease. Biol Blood Marrow Transplant. 2003;9:215-33.
20. Higman MA, Vogelsang GB. Chronic graft versus host disease. Br J Haematol. 2004;125(4):435-54.
21. Zadik Y, Zeevi I, Luboshitz-Shon N, Dakwar N, Wolff A, Shapira MY, Or R, Elad S. Safety and efficacy of an intra-oral electrostimulator for the relief of dry mouth in patients with chronic graft versus host disease: Case series. Med Oral Patol Oral Cir Bucal. 2014;19(3):e212-9.
22. Lafaurie G, Fedele S, López RM, Wolff A, Strietzel F, Porter SR, Konttinen YT. Biotechnological advances in neuro-electro-stimulation for the treatment of hyposalivation and xerostomia. Med Oral Patol Oral Cir Bucal. 2009;14(2):E76-80.
23. Ami S, Wolff A. Implant-supported electrostimulating device to treat xerostomia: a preliminary study. Clinical Implant Dentistry and Related Research. 2010;12(1):62-71.
How to Cite
KHURSHID, Zohaib et al. Saliva Electro-stimulation Devices (SEDs) for the Management of Xerostomia: An update.. Journal of Oral Research, [S.l.], p. 21-26, july 2020. ISSN 0719-2479. Available at: <>. Date accessed: 24 july 2021. doi: