Perception and acceptance of the use of 0.2% polyhexanide versus 0.12% chlorhexidine digluconate in patients at a risk of developing oral mucositis.
AbstractObjective: To evaluate the perception and acceptance of using polyhexanide (PHMB) and chlorhexidine digluconate (CLX) in individuals at a risk of developing oral mucositis induced by chemoradiotherapy. Materials and Methods: This is a randomised comparative study. Participants were randomised into two groups: Group 1 (PHMB 0.2%) and Group 2 (CLX 0.12%), these groups performed a mouth rinse with the respective solutions for 1 minute every 12 hours during an antineoplastic treatment cycle. The participants were evaluated at three different times: before (t0), during (t1) and after a cycle of antineoplastic treatment (t2). Severity of oral mucositis (OM), mouth pain, quality of life (OHIP-14), oral hygiene index and assessment of the acceptance of the substances in the mouth were assessed. Results: There were 23 individuals, 12 in Group 1 (G1) and 11 in Group 2 (G2). Both groups presented with OM in all three evaluations. Reported mouth pain was lower in G1 than in G2. The PHMB had a better acceptance (p=0.012) than the CLX for the time of mouth rinse at t0. There was a lower impact in the quality of life from oral health in the physical pain aspect (p=0.019) and in social incapacity (p=0.037) in G1 than in G2. Conclusions: PHMB has the same acceptance compared to CLX and is a good option for antiseptic mouth rinse with less adverse effects.
2. Mashat BH. Polyhexamethylene biguanide hydrochloride: Features and applications. BJES. 2016;4:49-55.
3. Elad S, Zadik Y, Yarom N. Oral complications of nonsurgical câncer therapies. Atlas Oral Maxillofac Surg Clin North Am. 2017;25:133-47
4. Cardona A, Balouch A, Abdul MM, Sedghizadeh PP, Enciso R. Efficacy of chlorhexidine for the prevention and treatment of oral mucositis in cancer patients: a systematic review with meta-analyses. J Oral Pathol Med. 2017;46:680-8.
5. Uzer Celik E, Tunac AT, Ates M, Sen BH. Antimicrobial activity of different disinfectants against cariogenic microorganisms. Braz Oral Res. 2016;30:e125.
6. Koburger T, Hübner NO, Braun M, Siebert K, Krames A. Standardized comparison of antiseptic afficacy of triclosan, PVP-iodine, octenidine dihydrochloride, polyhexanide and chlorhexidine digluconate. J Antimicrob Chemother. 2010;65:1712-19
7. Kramer A, Dissemond J, Kim S, Willy C, Mayer D, Papke R, Tuchmann F, Assadian O. Consensus on Wound Antisepsis: Update 2018. Skin Pharmacol Physiol. 2018;31(1):28-58.
8. Reddersen K, Wiegand C, Elsner P, Hipler UC. Three-dimensional human skin model infected with Staphylococcus aureus as a tool for evaluation of bioactivity and biocompatibility of antiseptics. Int J Antimicrob Agents. 2019;54:283-291.
9. Moore M, Dobson N, Cetnarowski W. 0.1% Polyhexanide-Betaine Solution as an Adjuvant in a Case-Series of Chronic Wounds. Surg Technol Int. 2016;26:85-9
1o. Cho P, Boost MV. Evaluation of prevention and disruption of biofilm in contact lens cases. Ophthalmic Physiol Opt. 2019;39:337-49
11. Walsh T, Oliveira-Neto JM, Moore D. Chlorhexidine treatment for the prevention of dental caries in children and adolescents. Cochrane Database Syst Rev. 2015;4:CD008457
12. Ciprandi G, Ramsay S, Budkevich L, Strack A, van Capellen P, Marathovouniotis N. A retrospective systematic data review on the use of a polihexanide-containing product on burns in children. J Tissue Viability. 2018;27:244-48
13. Payne B, Simmen HP, Csuka E, Hintzpeter M, Pahl S, Brill FHH. Randomized controlled clinical trial on the antiseptic efficacy of polihexanide 0,04% on acute traumatic wounds. J Hosp Infect. 2018;98:429-32
14. Aghamohamamdi A, Hosseinimehr SJ. Natural Products for Management of Oral Mucositis Induced by Radiotherapy and Chemotherapy. Integr Cancer Ther. 2016;15:60-8.
15. Sroussi HY, Epstein JB, Bensadoun RJ, Saunders DP, Lalla RV, Migliorati CA, Heaivilin N, Zumsteg ZS. Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med. 2017 Dec;6(12):2918-2931.
16. Franco P, Martini S, Di Muzio J, Cavallin C, Arcadipane F, Rampino M, Ostellino O, Pecorari G, Garzino Demo P, Fasolis M, Airoldi M, Ricardi U. Prospective assessment of oral mucositis and its impact on quality of life and patient-reported outcomes during radiotherapy for head and neck cancer. Med Oncol. 2017;34(5):81.
17. World Health Organization. Handbook for reporting results of cancer treatment. Geneve: WHO. 1979.
18. Wallerstein SL. Scaling clinical pain and pain relief. In: Bromm B, ed. Pain measurement in man: neurophysiological correlates of pain. New York: Elsevier, 1984.
19. Slade, G. Derivation and validation of a short-form oral impact profile. Community Dent Oral Epidemiol. 1997;25:284–90.
20. Greene JC, Vermillion JR. The simplified oral hygiene index. J Am Dent Assoc. 1964;68:7-13.
21. Welk A, Splieth CH, Schmidt-Martens G, Schwahn Ch, Kocher T, Kramer A, Rosin M. The effect of a polyhexamethylene biguanide mouthrinse compared with a triclosan rinse and a chlorhexidine rinse on bacterial counts and 4-day plaque re-growth. J Clin Periodontol. 2005;32(5):499-505.
22. Aghamohamamdi A, Hosseinimehr SJ. Natural Products for Management of Oral Mucositis Induced by Radiotherapy and Chemotherapy. Integr Cancer Ther. 2016;15:60-8.
23. PPonticelli E, Clari M, Frigerio S, De Clemente A, Bergese I, Scavino E, Bernardini A, Sacerdote C. Dysgeusia and health-related quality of life of cancer patients receiving chemotherapy: A cross-sectional study. Eur J Cancer Care (Engl). 2017 Mar;26(2). 1-7
24. Okada N, Hanafusa T, Abe S, Sato C, Nakamura T, Teraoka K, Abe M, Kawazoe K, Ishizawa K. Evaluation of the risk factors associated with high-dose chemotherapy-induced dysgeusia in patients undergoing autologous hematopoietic stem cell transplantation: possible usefulness of cryotherapy in dysgeusia prevention. Support Care Cancer. 2016;24(9):3979-85.
25. Rosin M, Welk A, Bernhardt O, Ruhnau M, Pitten FA, Kocher T, Kramer A. Effect of a polyhexamethylene biguanide mouthrinse on bacterial counts and plaque. J Clin Periodontol. 2001;28(12):1121-6.
The copyright of all the articles published in the J Oral Res. belongs to the Universidad de Concepción, Chile. All information about theJ Oral Res. is licensed under Creative Commons Attribution License 3.0 and must be cited correctly.