Lymphocyte B and Th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants.

  • Alejandra Chaparro Universidad de Los Andes, Department of Periodontology, Centre for Biomedical Research, Faculty of Dentistry, Santiago, Chile.
  • Antonio Sanz Universidad de Los Andes, Department of Periodontology, Centre for Biomedical Research, Faculty of Dentistry, Santiago, Chile.
  • Andrei Wolnitzky Universidad de Los Andes, Department of Periodontology, Centre for Biomedical Research, Faculty of Dentistry, Santiago, Chile.
  • Ornella Realini Universidad de Los Andes, Department of Periodontology, Centre for Biomedical Research, Faculty of Dentistry, Santiago, Chile.
  • María José Bendek Universidad de Los Andes, Department of Periodontology, Centre for Biomedical Research, Faculty of Dentistry, Santiago, Chile.
  • Daniel Betancur Universidad de Concepción, Department of Surgical Stomatology, Periodontology Discipline and Postgraduate Program in Periodontology, School of Dentistry, Concepción, Chile.
  • Daniela Albers Department of Statistics, School of Dentistry, Faculty of Science, Universidad Mayor, Santiago Chile.
  • Víctor Beltrán Universidad de La Frontera, Dental School, Clinical Investigation and Dental Innovation Center (CIDIC) and Center for Translational Medicine (CEMT-BIOREN), Temuco, Chile.

Abstract

Peri-implantitis is one of the leading causes of implant failure and loss, and its early diagnosis is not currently feasible due to the low sensitivity of currents methods. In the current exploratory cross-sectional study, we explored the diagnostic potential of lymphocyte B and Th17-chemotactic cytokine levels in peri-implant crevicular fluid (PICF) in 54 patients with healthy, peri-mucositis, or peri-implantitis implants. Peri-implant crevicular fluid was collected, and the levels of the molecules under study were quantified by Luminex assay. The concentrations of CCL-20 MIP-3 alpha, BAFF/BLYS, RANKL and OPG concentration in PICF were analyzed in the context of patient and clinical variables (smoking status, history of periodontitis, periodontal diagnosis, implant survival, suppuration, bleeding on probing, periodontal probing depth, clinical attachment level, mean of implant probing depth, and plaque index). Patients with peri-implantitis, appear to have an overregulation of the RANKL/BAFF-BLyS axis. This phenomenon needs to be investigated in depth in further studies with a larger sample size.

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Published
2020-07-01
How to Cite
CHAPARRO, Alejandra et al. Lymphocyte B and Th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants.. Journal of Oral Research, [S.l.], p. 20-25, july 2020. ISSN 0719-2479. Available at: <https://joralres.com/index.php/JOR/article/view/joralres.2020.029>. Date accessed: 24 july 2021. doi: https://doi.org/10.17126/joralres.2020.029.
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Articles