Frequency of high-risk genotypes of human papilloma virus in oral lesions.
AbstractSome genotypes of the human papilloma virus (HPV) in the oral cavity cause genetic instability that may lead to cancer. Clinical and histological diagnoses are key tools; however, molecular techniques allow predicting, detecting and monitoring the disease. Objective: To identify the frequency of four high-risk HPV genotypes and their association with lesions in the oral cavity. Materials and Methods: Descriptive cross-sectional study with a sample of 48 patients diagnosed with hyperplastic lesions and others currently classified as potentially malignant disorders (PMDs) of the oral cavity, who underwent biopsies, histopathological analysis, and HPV16, 18, 31, and 45 detection and genotyping by polymerase chain reaction (PCR). Results: Epithelial hyperplasia was the most frequent lesion found in 45.8% (n=22) of patients. Nicotine palatinus and leukoplakia were found in 8.3% and 6.2%, respectively; oral cancer in 6.2%. The total frequency of HPV was 12.5% (6/48). Oral papilloma was found in 6.1% (3/48), and nicotine palatinus and oral cancer in 2.0% each (1/48). HPV16, HPV31, and HPV45 were detected, while HPV18 was not observed. HPV16 was the most frequent genotype found (4 out of 6 patients), while HPV31 and HPV45 were found in one patient each. Only one genotype per lesion was found. The presence of HPV was associated with lesions (χ2=11.810; p=0.0375). No significant association with age and gender was found. Conclusion: High-risk HPV continues to be present in oral lesions. The HPV16 viral genotype was the most frequent in the studied lesions.
2. Rettig E, Kiess AP, Fakhry C. The role of sexual behavior in head and neck cancer: implications for prevention and therapy. Expert Rev Anticancer Ther. 2015;15(1):35-49.
3. Rebolledo Cobos M, Arango Fernández H, Rebolledo Cobos R, Alonso Brujes I. Rol del virus del papiloma humano en el desarrollo de carcinoma oral: una revisión. Av Odontoestomatol. 2016; 32(3): 135-44.
4. Rebolledo Cobos M, Yañez Torregroza Z. Susceptibilidad genética frente al cáncer bucal por infección del virus del papiloma humano. Gac Med Mex. 2019;155:284-90.
5. Cab-Sánchez BG, Hernández-Solís SE, Rueda-Gordillo F, Conde-Ferráez L, Gómez-Carballo JG, González-Losa MDR. [Epidemiology of oral HPV infection in young healthy individuals]. Rev Chilena Infectol. 2017;34(6):557-62.
6. Yete S, D'Souza W, Saranath D. High-Risk Human Papillomavirus in Oral Cancer: Clinical Implications. Oncol. 2018;94(3):133-41
7. Chai RC, Lambie D, Verma M, Punyadeera C. Current trends in the etiology and diagnosis of HPV-related head and neck cancers. Cancer Med. 2015;4(4):596-607.
8. Rettig E, Kiess AP, Fakhry C. The role of sexual behavior in head and neck cancer: implications for prevention and therapy. Expert Rev Anticancer Ther. 2015;15(1):35-49.
9. Martínez Martínez A, Baldiris Ávila R, Díaz Caballero A. Pa-piloma bucal producido por VPH y su relación con carcinoma. Rev Clín Med Fam. 2012; 5 (2): 144-5
10. Chen X, Zhao Y. Human papillomavirus infection in oral potentially malignant disorders and cancer. Arch Oral Biol. 2017;83:334-9.
11. Gupta S. Role of human papillomavirus in bucal squamous cell carcinoma and bucal potentially malignant disorders: A review of the literature. Indian J Dent. 2015;6(2):91-8.
12. Prabhu SR, Wilson DF. Human papillomavirus and bucal disease – emerging evidence: a review. Aust Dental J. 2013; 58 (1): 2-10.
13. Contreras W, Venegas B. Virus Papiloma Humano en Cáncer Oral y Orofaríngeo: Revisión de la Literatura. Int J Odontostomat. 2015; 9(3): 427-35.
14. Ramírez V, Vásquez-Rozas P, Ramírez-Eyraud P. Mortalidad por cáncer oral y faríngeo en Chile, años 2002-2010. Rev Clin Periodoncia Implantol Rehabil Oral. 2015;8(2):133-8
15. Gillison ML, Koch WM, Shah KV. Human papillomavirus in head and neck squamous cell carcinoma: are some head and neck cancers a sexually transmitted disease? Curr Opin Oncol. 1999; 11: 191-9.
16. Molijn A, Kleter B, Quint W, van Doorn YL. Molecular diagnosis of human papillomavirus (HPV) infections. J Clin Vir. 2005; 32 (Suppl 1): S43-51
17. Miller CS, White DK. Human papillomavirus expression in bucal mucosa, premalignant conditions, and squamous cell carcinoma: a retrospective review of the literature. Bucal Surg Bucal Med Bucal Pathol Bucal Radiol Endod. 1996; 82: 57-68.
18. Parisi SG, Basso M, Scaggiante R, Andreis S, Mengoli C, Cruciani M, Del Vecchio C, Menegotto N, Zago D, Sarmati L, Andreoni M, Palù G. Oral and anal high-risk human papilloma virus infection in HIV-positive men who have sex with men over a 24-month longitudinal study: complexity and vaccine implications. BMC Public Health. 2019; 19(1):645.
19. Kero K, Rautava J. HPV Infections in Heterosexual Couples: Mechanisms and Covariates of Virus Transmission. Acta Cytol. 2019;63(2):143-147.
20. Jamieson L, Garvey G, Hedges J, Mitchell A, Dunbar T, Leane C, Hill I, Warren K, Brown A, Ju X, Roder D, Logan R, Johnson N, Smith M, Antonsson A, Canfell K. Human Papillomavirus and Oropharyngeal Cancer Among Indigenous Australians: Protocol for a Prevalence Study of Oral-Related Human Papillomavirus and Cost-Effectiveness of Prevention. JMIR Res Protoc. 2018;7(6):e10503
21. Ashraf MJ, Hosseini S, Monabati A, Valibeigi B, Khademi B, Abedi E, Azarpira N. The Prevalence of Human Papilloma Virus in Squamous Cell Carcinoma of Oral Tongue. Iran J Pathol. 2017;12(2):144-9.
22. Hettmann A, Demcsák A, Bach Á, Decsi G, Dencs Á, Pálinkó D, Rovó L, Terhes G, Urbán E, Buzás K, Nagy K, Takács M, Minarovits J. Prevalence and genotypes of human papillomavirus in saliva and tumor samples of head and neck cancer patients in Hungary. Infect Genet Evol. 2018;59:99-106.
The copyright of all the articles published in the J Oral Res. belongs to the Universidad de Concepción, Chile. All information about theJ Oral Res. is licensed under Creative Commons Attribution License 3.0 and must be cited correctly.