Comparison of Ostene® and Bone wax on Bone Healing: A Comparative experimental study in rabbits.

Huda A. Salim


Introduction: Ostene® is a new synthetic bone hemostatic wax-like inert and biocompatible material that dissolves within two days after application. Bone wax is a well- known topical hemostatic agent, easy to use, and its application is very simple. Wound healing is a complex biological process; Bone is a dynamic tissue that is continuously resorbed, renewed, and remodeled.  Materials and methods: Twenty domestic rabbits were divided into four groups (day 1, day 3, day 7, and day 14). Each rabbit was anaesthetized and three holes were drilled in the mandible: one was filled with Ostene®, another with bone wax, and the other was left unfilled as control. Sites of intervention were assessed by histopathology. Results and Discussion: Ostene® and bone wax showed osteoinductive property in bone healing with no inflammatory reaction. Our study revealed new bone formation within 14 days in Ostene® group. After histopathological analysis and scoring was finished, analysis by SPSS 14 software showed a significant difference between the use of Ostene® and bone wax. Conclusion: Ostene® showed superiority over bone wax in bone healing, and it can be used in the same way as bone wax with no interference with bone healing and osteogenesis. Ostene® has no side effects following application.


Comparación de Ostene® y cera ósea en la curación ósea: Un estudio experimental comparativo en conejos.

Introducción: Ostene® es un nuevo material biocompatible inerte y ceroso hemostático de hueso sintético que se disuelve dentro de los dos días posteriores a la aplicación. La cera ósea es un agente hemostático tópico bien conocido, fácil de usar y su aplicación es muy simple. La curación de heridas es un proceso biológico complejo. El hueso es un tejido dinámico que se reabsorbe, renueva y remodela continuamente. Materiales y métodos: Veinte conejos domésticos se dividieron en cuatro grupos (día 1, día 3, día 7 y día 14). Cada conejo se anestesió y se perforaron tres orificios en la mandíbula: uno se llenó con Ostene®, otro con cera ósea y el otro se dejó sin rellenar como control. Los sitios de intervención fueron evaluados por histopatología. Resultados y Discusión: Ostene® y la cera ósea mostraron propiedades osteoinductoras en la curación ósea sin reacción inflamatoria. Nuestro estudio reveló la formación de hueso nuevo dentro de los 14 días en el grupo Ostene®. Una vez finalizado el análisis histopatológico y la puntuación, el análisis mediante el software SPSS 14, mostró una diferencia significativa entre el uso de Ostene® y la cera ósea. Conclusión: Ostene® mostró superioridad sobre la cera ósea en la curación ósea, y se puede usar de la misma manera que la cera ósea sin interferencia con la curación ósea y la osteogénesis. Ostene® no tiene efectos secundarios después de la aplicación.


bone hemostatic agents; Ostene; bone wax; bone healing; alkylene oxide copolymers. Agentes hemostáticos óseos; Ostene, cera de hueso; curación ósea; copolímeros de óxido de alquileno.


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