Serum vitamin B12 associated with vitamin D/25(OH)D in women with recurrent aphthous stomatitis.
AbstractVitamin B12 and Vitamin D deficiency may contribute to recurrent aphthous stomatitis (RAS). Current studies have showed vitamin B12 to be associated with vitamin D in women, however no study has assessed vitamin B12 associated with vitamin D/25(OH)D in women with RAS. Objective: To investigate the association between serum vitamin B12 and vitamin D/25(OH)D in women with RAS. Materials and Methods: Fourty one women with RAS who meet the inclusion criteria participated in this study. The inclusion criteria were women with RAS without other oral diseases. The exclusions criteria were those who have systemic diseases, taking medications or smoked. All subjects underwent venupuncture to draw blood to quantify serum vitamin B12 and vitamin D/25(OH)D. The characteristic of subjects, severity of RAS, serum Vitamin B12 and Vitamin D/25(OH)D were collected and presented descriptively. The correlation between vitamin B12 and Vitamin D/25(OH)D was analyzed using Pearson correlation test with 95% confidence interval. This study was approved by Medical and Health Ethics Committe, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia. Results: All RAS subjects have normal mean value of serum Vitamin B12 (453.97+154.44pg/ml) and have low mean value of serum vitamin D/25(OH)D (10.79 +3.29ng/ml) categorized as vitamin D deficiency. The Pearson correlation test showed that there was a significant positive correlation between mean serum Vitamin B12 and Vitamin D/25(OH)D (r= 0.313, p<0.05). Conclusion: There is correlation between vitamin B12 and Vitamin D, and a low level of Vitamin D may contribute in RAS in women.
2. Scully C, Porter S. Oral mucosal disease: recurrent aphthous stomatitis. Br J Oral Maxillofac Surg. 2008;46(3):198-206.
3. Preeti L, Magesh K., Rajkumar K, Raghavendhar Karthik. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol. 2011;15(3):252–6.
4. Ślebioda Z, Szponar E, Kowalska A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: Literature review. Arch Immunol Ther Exp (Warsz). 2014;62(3):205-15.
5. Adeyemo T, Adediran A, Akanmu A, Adeyemo W, Akinbami AJ. Orofacial manifestations of hematological disorders: Anemia and hemostatic disorders. Indian J Dent Res. 2011;22(3):454.
6. Schlosser BJ, Pirigyi M, Mirowski GW. Oral manifestations of hematologic and nutritional diseases. Otolaryngol Clin North Am. 2011;44(1):183-203.
7. Kozlak ST, Walsh SJ, Lalla R V. Reduced dietary intake of vitamin B12 and folate in patients with recurrent aphthous stomatitis. Natl Inst Heal Public Access. 2012;39(5):420-3.
8. Ghosh A, Pallavi S, Nagpal B, Hedge U, Archana S, Nagpal J. Role of Vitamins in Oral Health & Disease : an Overview. Indian J Appl Res. 2015;5(12):292-5.
9. Piskin S, Sayan C, Durukan N, Senol M. Serum iron , ferritin , folic acid , and vitamin B12 levels in recurrent aphthous stomatitis. J Eur Acad Dermatology Venereol. 2002;16:66-7.
10. Sun A, Chen HM, Cheng SJ, Wang YP, Chang JY, Wu YC, Chiang CP. Significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high homocysteine level with recurrent aphthous stomatitis. J Oral Pathol Med. 2015;44(4):300-305.
11. Sari K, Yildirim T, Sari N. The level of Vitamin B12 and hemoglobin in patients with recurrent aphthous stomatitis. Med J DY Patil Univ. 2016;9(5):605.
12. Ghafoor F, Khan AA. Association of Vitamin B12, Serum Ferritin and Folate Levels with Recurrent Oral Ulceration. Pak J Med Res. 2012;51(4):132-135.
13. Healy CM, Williams DM, Thornhill MH. Haematinic Deficiency in Recurrent Aphthous Stomatitis: its Prevalence and Response to Treatment. Oral Biosci Med. 2004;1:259-66.
14. Qazi JA. Vitamin B12 for the Treatment of Recurrent Aphthous Stomatitis. J Khyber Coll Dent. 2011;1(2):10-3.
15. Gulcan E, Toker S, Hatipoğlu H, Gulcan A, Toker A. Cyanocobalamin May be Beneficial in the Treatment of Recurrent Aphthous Ulcers Even When Vitamin B12 Levels Are Normal. Am J Med Sci. 2008;336(5):379-382.
16. Lalla R V, Choquette LE, Feinn RS, et al. Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial. J Am Dent Assoc. 2012;143(4):370-376.
17. Hietanen J, Häyrinen-Immonen R, Al-Samadi A, Trokovic N, Koskenpato K, Konttinen YT. Recurrent aphthous ulcers-a Toll-like receptor-mediated disease? J Oral Pathol Med. 2012;41(2):158-164.
18. Gallo C, Barros F, Sugaya N, Nunes F, Borra R. Differential expression of toll-like receptor mRNAs in recurrent aphthous ulceration. J Oral Pathol Med. 2012;41:80-85.
19. Karasneh J, Bani-Hani M, Alkhateeb A, Hassan A, Alzoubi F, Thornhill M. TLR2, TLR4 and CD86 gene polymorphisms in recurrent aphthous stomatitis. J oral Pathol Med. 2015;44(10):857-63.
20. Borra RC, de Mesquita Barros F, de Andrade Lotufo M, Villanova FE, Andrade PM. Toll-like receptor activity in recurrent aphthous ulceration. J Oral Pathol Med. 2009;38(3):289-98.
21. Ujević A, Lugović-Mihić L, Šitum M, Ljubešić L, Mihić J, Troskot N. Aphthous Ulcers As a Multifactorial Problem. Acta Clin Croat. 2013;52(52):213-21.
22. Volkov I, Rudoy I, Abu-Rabia U, Masalha T, Masalha R. Case report: Recurrent aphthous stomatitis responds to vitamin B12 treatment. Can Fam Physician. 2005;51(JUNE):844-5.
23. Barros FM, Lotufo A, Andrade PM, Franc CM, Borra RC. Possible Association between Th1 Immune Polarization and Epithelial Permeability with Toll-Like Receptors 2 Dysfunction in the Pathogenesis of the Recurrent Aphthous Ulceration. Ulcers. 2010;10:1-11.
24. Challacombe SJ, Alsahaf S, Tappuni A. Recurrent Aphthous Stomatitis: Towards Evidence-Based Treatment ? Curr oral Heal Reports. 2015;2:158-67.
25. Khabbazi A, Ghorbanihaghjo A, Fanood F, Kolahi S, Hajialiloo M, Rashtchizadeh N. A comparative study of vitamin D serum levels in patients with recurrent aphthous stomatitis. Egypt Rheumatol. 2015;37(3):133-7.
26. Stagi S, Bertini F, Rigante D, Falcini F. Vitamin D levels and effects of vitamin D replacement in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. Int J Pediatr Otorhinolaryngol. 2014;78(6):964-8.
27. Krawiecka E, Slebioda Z, Szponar E, et al. Vitamin D status in recurrent aphthous stomatitis. Adv Dermatology Allergol. 2017;34(6):612-7.
28. Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013;5(7):2502-21.
29. Aranow C. Vitamin D and The Immune System. J Investig Med. 2012;59(6):881-6.
30. Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: Modulator of the immune system. Curr Opin Pharmacol. 2010;10(4):482-96.
31. DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004;80(6 Suppl):1689-96.
32. Khoo AL, Chai LY, Koenen HJ, Sweep FC, Joosten I, Netea MG, van der Ven AJ. Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals. Clin Exp Immunol. 2011;164(1):72-79.
33. Ojaimi S, Skinner NA, Strauss BJG, Sundararajan V, Woolley I, Visvanathan K. Vitamin d deficiency impacts on expression of toll-like receptor-2 and cytokine profile : a pilot study. J Transl Med. 2013;11(176).
34. Calton EK, Keane KN, Newsholme P, Soares MJ. The impact of Vitamin D levels on inflammatory status: A systematic review of immune cell studies. PLoS One. 2015;10(11):1-12.
35. Curic N, Ilincic B, Milic N, et al. The relationship between the vitamin serum 25(OH)D and the B12 concentrations in Obese women. Minerva Med. 2018;109(2):79-87.
36. Ajmal M, Ibrahim L, Mohammed N, Al-Qarni H. Prevalence and Psychological Stress in Recurrent Aphthous Stomatitis Among Female Dental Students in Saudi Arabia. Clujul Med. 2018;91(2):216
37. Abdullah MJ. Prevalence of recurrent aphthous ulceration experience in patients attending piramird dental speciality in sulaimani city. J Clin Exp Dent. 2013;5(2):2-7.
38. Tappuni AR, Kovacevic T, Shirlaw PJ, Challacombe SJ. Clinical assessment of disease severity in recurrent aphthous stomatitis. J Oral Pathol Med. 2013;42(0):635-641.
39. Bruce AJ, Rogers RS. Acute oral ulcers. Dermatol Clin. 2003;21(1):1-15.
40. Muñoz-Corcuera M, Esparza-Gómez G, González-Moles MA, Bascones-Martínez A. Oral ulcers: clinical aspects. A tool for dermatologists. Part I. Acute ulcers. Clin Exp Dermatol. 2009;34:289-294.
41. Agmon-levin N, Theodor E. Vitamin D in Systemic and Organ-Specific Autoimmune Diseases. 2013:256-266.
42. Borges MC, Martini LA, Rogero MM. Current perspectives on vitamin D , immune system , and chronic diseases. Nutrition. 2011;27(4):399-404.
43. Kulie T, Groff A, Redmer J, Hounshell J. Vitamin D : An Evidence-Based Review. J Am Board Fam Med. 2009;22(6):698-706.
44. Hudson J. Recurrent Aphthous Stomatitis: Diagnosis and Management in Primary Care. J Patient-Centered Res Rev. 2014;1(4):197-200.
45. Benson AA, Toh JA, Vernon N, Jariwala SP. The role of vitamin D in the immunopathogenesis of allergic skin diseases. Eur J Allergy Clin Immunol. 2012;67(2):296-301.
46. Shams B, Afshari E, Tajadini M, Keikha M, Qorbani M, Heshmat R, Motlagh ME, Kelishadi R. Relationship of Serum Vitamin D and Zinc in a Nationally - Representative Sample of Iranian children and Adolescents: The CASPIAN - III Study. Mecdical J Islam Repub Iran. 2016;30(430):1-5
47. Hyun Y, Nan Young B, Mi Young G, Bu Yeon P, Jeong Min S. The Association between serum ferritin and 25-hydroxyvitamin D and metabolic syndrome in Korean Women : the Korea national Heath and Nutrition examination Survey 2010-2012. J Clin Biochem Nutr. 2017;(June):1-7.
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