Salivary rheumatoid factor in primary and secondary Sjögren’s syndrome.

  • Gloria Martínez-Sandoval School of Dentistry, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
  • Silvia Triana-Reyes School of Dentistry, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
  • Norma Rodríguez-Franco School of Dentistry, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
  • María Chapa-Arizpe School of Dentistry, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
  • Jesús Rodríguez-Pulido School of Dentistry, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
  • Andrea Alcázar-Pizaña Centro de Investigación y Desarrollo en Ciencias de la Salud, Monterrey, Nuevo León, México.
  • Janett Riega-Torres Centro de Especialistas en Artritis y Reumatismo, Hospital Universitario. Monterrey, Nuevo León, México.

Abstract

Sjögren's syndrome is a chronic autoimmune disease, characterized by the presence of hyposalivation and xerophthalmia, which in addition to other factors is diagnosed by the presence of rheumatoid factor in blood. The objective of the present study is to evaluate the presence of rheumatoid factor (IgG-IgM) in the saliva of patients with primary and secondary Sjögren's syndrome. Materials and methods: Forty samples from patients with primary and secondary Sjögren's syndrome previously diagnosed by the Arthritis and Rheumatism Specialist Center of the Autonomous University of Nuevo Leon were analyzed. Samples were taken from the saliva using the Carlson-Crittenden device to evaluate the IgG-IgM immunocomplex using the ELISA method. Results: No significant difference was found between the presence of IgM in primary (0.099±0.016) and secondary Sjögren syndrome (0.098±0.017), however, a high presence of IgG was found in the group of patients with secondary Sjögren's syndrome (0.134±0.054). Conclusion: The search for diagnostic tools using salivary biomarkers has come with economic and clinical advantages, however, in the present study no significant changes were found in salivary rheumatoid factor between both groups.

References

1. Yoshimoto K, Fujimoto T, Itaya A, Miyaoka T, Sakuramoto S, Yamauchi A, Takeda M, Kasai T, Nakagawara K, Nonomura A, Takasawa S. Involvement of autoimmunity to REG, a regeneration factor, in patients with primary Sjögren’s syndrome. Clin Exp Immunol. 2013;174(1):1–9.
2. Maślińska M, Przygodzka M, Kwiatkowska B, Sikorska-Siudek K. Sjögren’s syndrome: still not fully understood disease. Rheumatol Int. 2015;35(2):233–241.
3. Rodríguez-Pulido J, Martínez-Sandoval G, Rodríguez-Franco N, Chapa-Arizpe M, Riega-Torres J, Garza-Elizondo M. Salivary stimulation by prolonged release of pilocarpine in Sjögren’s syndrome. J Oral Res. 2017;6(3):65-69.
4. Rodríguez J, Martínez G, Rodríguez N, Chapa M, Solis J. Dental perspective on Sjögren’s syndrome: literature review. J Oral Res. 20;4(3):211–222.
5. Triana SA, Rodríguez JI, Garza BR, Martínez G, Rodríguez NI. Relación entre Periodontitis y Artritis reumatoide. Odontol Actual. 2016;13(160):44–47.
6. Shahane A, Patel R. The epidemiology of Sjögren's syndrome. Clin Epidemiol. 2014;6(1):247-255.
7. Rodríguez J, Sánchez R, Garza M, Nakagoshi M, Solis J, Arévalo K, Garza E. Salivary stimulation by prolonged release of pilocarpine using films in diabetic rats. J Oral Res. 2015;4(2):103–8.
8. Rodríguez J, Sánchez R, Garza M, Nakagoshi M, Solís J, Arévalo K, Garza E. Physicochemical and antimicrobial evaluation of chitosan and hydroxypropyl methylcellulose films for prolonged release of pilocarpine. J Oral Res. 2015;4(1):25–31.
9. Rodríguez JI, Martínez G, Rodríguez NI, Chapa MG, Solís JM. Terapia farmacológica y avances terapéuticos en xerostomía e hiposalivación. Rev ADM. 2017;74(5):221-223.
10. Shiboski SC, Shiboski CH, Criswell LA, Baer AN, Challacombe S, Lanfranchi H, Schiødt M, Umehara H, Vivino F, Zhao Y, Dong Y, Greenspan D, Heidenreich AM, Helin P, Kirkham B, Kitagawa K, Larkin G, Li M, Lietman T, Lindegaard J, McNamara N, Sack K, Shirlaw P, Sugai S, Vollenweider C, Whitcher J, Wu A, Zhang S, Zhang W, Greenspan J, Daniels T. American College of Rheumatology classification criteria for Sjögren’s syndrome: A data-driven, expert consensus approach in the Sjögren’s International Collaborative Clinical Alliance Cohort. Arthritis Care Res. 2012;64(4):475–87.
11. Aletaha D, Alasti F, Smolen JS. Rheumatoid factor determines structural progression of rheumatoid arthritis dependent and independent of disease activity. Ann Rheum Dis. 2013;72(6):875-880.
12. Terao C, Yamakawa N, Yano K, Markusse IM, Ikari K, Yoshida S, Furu M, Hashimoto M, Ito H, Fuji T, Ohmura K, Murakami K, Takahashi M, Hamaguchi M, Tabara Y, Taniguchi A, Momohara S, Raychaudhuri S, Allaart CF, Yamanaka H, Mimori T, Matsuda F. Rheumatoid Factor Is Associated With the Distribution of Hand Joint Destruction in Rheumatoid Arthritis. Arthritis Rheumatol. 2015;67(12):3113-3123.
13. Lawrence HP. Salivary markers of systemic disease: noninvasive diagnosis of disease and monitoring of general health. J Can Dent Assoc. 2002;68(3):170–5.
14. Agrawi LA, Galtung HK, Vestad B, Øvstebø R, Thiede B, Rusthen S, Young A, Guerreiro EM, Utheim TP, Chen X, Utheim ØA, Palm Ø, Jensen JL. Identification of potential saliva and tear biomarkers in primary Sjögren's syndrome, utilising the extraction of extracellular vesicles and proteomics analysis. 2017;19(1):1-14.
15. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH. Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002;61(6):554–8.
16. Ingegnoli F, Castelli R, Gualtierotti R. Rheumatoid factors: Clinical Applications. Dis Markers. 2013;35(6):727-34.
17. Deutsch O, Krief G, Konttinen YT, Zaks B, Wong DT, Aframian DJ, Palmon A. Identification of Sjögren’s syndrome oral fluid biomarker candidates following high-abundance protein depletion. Rheumatology. 2015;54(5):884:890.
18. Moutsopoulos HM, Zerva LV. Anti-Ro (SSA)/La (SSB) antibodies and Sjögren’s syndrome. Clin rheumatol. 1990;1(1):123-31.
19. German AJ, Hall EJ, Day MJ. Measurement of IgG, IgM and IgA concentrations in canine serum, saliva, tears and bile. Vet Immunol Immunopathol. 1998;64(2):107-121.
Published
2019-08-21
How to Cite
MARTÍNEZ-SANDOVAL, Gloria et al. Salivary rheumatoid factor in primary and secondary Sjögren’s syndrome.. Journal of Oral Research, [S.l.], v. 8, n. 3, p. 196-200, aug. 2019. ISSN 0719-2479. Available at: <http://joralres.com/index.php/JOR/article/view/853>. Date accessed: 17 sep. 2019. doi: https://doi.org/10.17126/jor.v8i3.853.
Section
Articles