The effects of bioadhesive hyaluronic acid gel versus diclofenac after surgical removal of impacted wisdom teeth.
AbstractSurgical extraction of impacted lower wisdom teeth is a frequent minor intraoral surgical process. It is regularly linked with aching and postoperative consequences as pain and swelling. The aim of this study is to evaluate the efficacy of two methods in reducing swelling and pain subsequent to the removal of impacted wisdom teeth. This randomized study incorporated 20 patients with impacted wisdom teeth of different surgical complexity. Topical hyaluronic acid gel 2g/2ml with aloe vera (Kin®Care) was given to the patients to be applied to the surgical area three times a day, or diclofenac sodium tablet 50mg (Voltaren®) to be taken every eight hours, for one week. Swelling was estimated using a strip gauge technique, and pain with a visual analogue scale. Evaluations were made on day one of surgical treatment and on 72hrs and one week later. Statistically no significant differences were identified regarding the swelling and pain values between the two treatment groups on the third and seventh day after surgery. Hyaluronic acid gel was as efficient as diclofenac tablets in reducing the two parameters. The use of hyaluronic acid may be advantageous in medically compromised patient such as those with hypertension, chronic asthma, gastric ulcers or in those with any contraindications to using non-steroidal anti-inflammatory drugs, or in pregnant patients to reduce pain and swelling subsequent to impacted wisdom teeth surgery.
2. Hunter JP, Simmonds MJ. Pain: putting the whole person at the centre. Physiotherapy Canada. 2010; 62:1–8.
3. Aya KL, Stern R. Hyaluronan in wound healing: rediscovering a major player. Wound Repair Regeneration. 2014;22(5):579–93.
4. Neuman MG, Nanau RM, Oruna-Sanchez L, Coto G. Hyaluronic acid and wound healing. J Pharm Pharm Scie. 2015;18(1):53–60.
5. Tammi MI, Day AJ, Turley EA. Hyaluronan and homeostasis :a balancing act. J Biol Chem. 2002;277(7):4581-4.
6. Gontiya G, Galgali SR. Effect of Hyaluronan on periodontitis: a clinical and histopathological study. J. Indian Soc Periodontol 2012;16(2): 184-92.
7. Koray M, Ofluoglu D, Onal EA, Ozgul M, Ersev H, Yaltirik M, Tanyeri H. Efficacy of Hyaluronic acid spray on swelling, pain and trismus after surgical extraction of impacted mandibular third molars. Int J Oral Max Surg. 2014;43(11):1399-1403.
8. Manuele C, Antonio M, Paola V, Lorenzo S, Francesco C, Beatrice S, Michele AL, Francesco C, Fabrizio S. Hyaluronic acid :perspectives in dentistry. A systemic review. Int J Immunopathol Pharmacol. 2016; 29(4): 572-82.
9. Hanci D, Alun H. Effectiveness of Hyaluronic acid in post tonsillectomy pain relief and wound healing: a retrospective, double blind, controlled clinical study. Int J Pediatr Otorhinolaryngol . 2015;79(9):1388-92.
10. Gocmen G, Aktop S, Tüzüner B, Goker B, Yarat A. Effects of Hyaluronic acid on bleeding following third molar extraction. J Appl Oral Scie. 2017;25(2):211-6.
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